The Effect of Virgin Coconut Oil (VCO) on Malondialdehyde, Glutathione Peroxidase, and Cortisol Hormone Levels

Vigorous physical activity is a movement that produces excessive free radicals due to leakage of electrons from the mitochondrial transport system. The body's antioxidant system reduced inability defenses reduce production resulting in oxidative stress, so it requires supply antioxidants outside body such as Virgin Coconut Oil (VCO). purpose this study determine effect VCO administration on malondialdehyde levels, glutathione peroxidase levels and cortisol hormone male Wistar rats subjected strenuous activity. research method uses an experimental with posttest only control group design. subjects were 24 which randomly divided into 4 groups (K1, K2, K3, K4). at dose 25 mL 50 are based human weight 70 kg conversion mice (BB = 200 g) resulted 0.45 mL/200 g BW/day 0.9 BW / day made 1 solution given orally for 28 days. K3 K4 BW/day. measurement using TBARS method. (GPx) ELISA PSPG UGM June 2022. lowest average MDA GPx K1 group. One-Way Anova test result showed malondialdehyde, peroxidase, had significant differences K2 (p < 0.05). doses could affect